Preparation of artemether/benflumetol compound fat emulsion for injection and application of artemether/benflumetol compound fat emulsion in malaria treatment

The invention discloses an artemether/benflumetol compound fat emulsion preparation which contains 0.01-1.5 percent by weight of artemether, 0.01-3.5 percent by weight of benflumetol, 10.0-30.0 percent by weight of injection oil, 0.6-30.0 percent by weight of emulsifier, 0-10 percent by weight of so...

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Bibliographic Details
Main Authors ZHAO WEN, CHEN TAO, MA YUFAN, LU TINGLI, WANG RUTAO, WANG WEIJIAO
Format Patent
LanguageChinese
English
Published 21.08.2013
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses an artemether/benflumetol compound fat emulsion preparation which contains 0.01-1.5 percent by weight of artemether, 0.01-3.5 percent by weight of benflumetol, 10.0-30.0 percent by weight of injection oil, 0.6-30.0 percent by weight of emulsifier, 0-10 percent by weight of solubilizer, 00.01-5 percent by weight of co-emulsifier, 2.25-7 percent by weight of isoosmolar agent, 0.002-0.075 percent of antioxidant and the balance of injection water. The invention further discloses a preparation method as well as pharmacodynamics and safety elevation of the artemether/benflumetol compound fat emulsion preparation. The artemether/benflumetol compound fat emulsion preparation has the characteristics of good biocompatibility, high physical stability, good safety, high medicament-loading capacity and the like and is convenient to prepare. An in-vivo pharmacodynamic animal experiment proves that the artemether/benflumetol compound fat emulsion preparation has a remarkably killing role in plasmodiu
Bibliography:Application Number: CN201310169852