Curcuminoid solid dispersion formulation

• Main Authors: DAS TAPAS, SATHYA SHREERAM, KESSLER THOMAS K, SCHNEIDER KATRIN, BREITENBACH JOERG, A .XU, PATEL GAURAV C
• Format: Patent
• Language: Chinese; English
• Published: 07.08.2013
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The invention provides a curcuminoid formulation comprising a melt-processed solid dispersion product comprising one or more curcuminoids, a nutritionally acceptable thermoplastic polymer, and a phosphatide. The formulation provides an improved oral bioavailability compared to a non-formulated crystalline curcuminoid. The invention provides a method for producing said formulation, and provides nutritional products fortified with said formulation. Said formulation is used in the treatment or prophylaxis of cancer, and relates to disease states of an inflammatory reaction, neurological disorders, cardiovascular diseases, pulmonary diseases, the formation of cholesterol gallstones, and parasitic infestation.