Carbidopa-levodopa controlled release tablet and preparation method of tablet

The invention relates to a carbidopa-levodopa controlled release tablet and a preparation method of the tablet. The total dose of the carbidopa-levodopa controlled release tablet in the prior art reaches 250mg, but the total weight of the tablet is very small, so that a certain degree of difficulty...

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Bibliographic Details
Main Authors WANG CHUANYUE, HE SHULIN, LI HUANGQIANG
Format Patent
LanguageChinese
English
Published 10.07.2013
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a carbidopa-levodopa controlled release tablet and a preparation method of the tablet. The total dose of the carbidopa-levodopa controlled release tablet in the prior art reaches 250mg, but the total weight of the tablet is very small, so that a certain degree of difficulty is brought to the production process and the industrial production is constrained. The carbidopa-levodopa controlled release tablet disclosed by the invention comprises the following substances in percentage by mass: 15-17% of carbidopa, 60-70% of levodopa, 1-5% of a controlled release material, 0-3% of an adhesive, 5-15% of a filler, 0-2% of a lubricant and 1-4% of a film-forming material. According to the invention, the technical problem caused by large dose and small weight of tablets is thoroughly solved through a one-step granulation and coating technique; a medicine release curve similar to that of imported medicines is acquired; and the industrial production is facilitated.
Bibliography:Application Number: CN20131137357