Novel long-acting glucagon-like peptide 1 (GLP-1) analogues and application thereof

The invention relates to novel long-acting glucagon-like peptide 1 (GLP-1) analogues and a synthesis method thereof. GLP-1 analogues with longer pharmacological action time are obtained through replacing/modifying 17th, 26th, 34th and 37th amino acids of natural GLP-1, the synthesis of target polype...

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Bibliographic Details
Main Authors HAN JING, LI ZHENG, CHU YINGYING, SUN LIDAN, QIAN HAI, HUANG WENLONG
Format Patent
LanguageChinese
English
Published 08.05.2013
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to novel long-acting glucagon-like peptide 1 (GLP-1) analogues and a synthesis method thereof. GLP-1 analogues with longer pharmacological action time are obtained through replacing/modifying 17th, 26th, 34th and 37th amino acids of natural GLP-1, the synthesis of target polypeptides is quickly realized through a microwave-promoted solid-phase synthesis method, and crude products are purified and freeze-dried to the GLP-1 analogues.
Bibliography:Application Number: CN20121513142