能够特异性结合组织因子途径抑制剂的抗体

本发明涉及能够特异性结合组织因子途径抑制剂（TFPI）、中和游离TFPI且减少血液的凝固时间的抗体。此外，本发明涉及编码此类抗体的多核苷酸和包含多核苷酸或表达本发明的抗体的细胞。此类抗体单独以及与第二种试剂的组合在具有凝血病的受试者治疗中具有效用。 The invention relates to antibodies that are capable of specifically binding tissue factor pathway inhibitor (TFPI), neutralising free TFPI and reducing the clotting time of b...

Full description

Saved in:
Bibliographic Details
Format Patent
LanguageChinese
Published 13.06.2017
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:本发明涉及能够特异性结合组织因子途径抑制剂（TFPI）、中和游离TFPI且减少血液的凝固时间的抗体。此外，本发明涉及编码此类抗体的多核苷酸和包含多核苷酸或表达本发明的抗体的细胞。此类抗体单独以及与第二种试剂的组合在具有凝血病的受试者治疗中具有效用。 The invention relates to antibodies that are capable of specifically binding tissue factor pathway inhibitor (TFPI), neutralising free TFPI and reducing the clotting time of blood. Furthermore, the invention relates to polynucleotides that encode such antibodies and to cells that comprise the polynucleotides or that express the antibodies of the invention. Such antibodies have utility in the treatment of subjects with a coagulopathy, alone as well as in combination with a second agent.
Bibliography:Application Number: CN201180031881