Penicillin G sulfoxide dimethyl formamide (DMF) composite crystal and preparation method thereof

The invention discloses a penicillin G sulfoxide dimethyl formamide (DMF) composite crystal and a preparation method thereof. The melting point of the composite crystal is not lower than 101 Celsius degrees. The element contents are that 53.6% of carbon (C), 9.9% of nitrogen (N), 22.8% of oxygen (O)...

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Bibliographic Details
Main Authors FU CHENGMING, MI ZHENRUI, ZHANG MIAOJING, WEI QINGJIE, DUAN ZHIGANG, ZHENG BAOLI
Format Patent
LanguageChinese
English
Published 24.04.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a penicillin G sulfoxide dimethyl formamide (DMF) composite crystal and a preparation method thereof. The melting point of the composite crystal is not lower than 101 Celsius degrees. The element contents are that 53.6% of carbon (C), 9.9% of nitrogen (N), 22.8% of oxygen (O), 5.9% of hydrogen (H) and 7.55% of sulfur (S). The preparation method is that firstly, the penicillin G sulfoxide is dissolved in the DMF water solution, the water solution containing the DMF or organic solution containing the DMF to obtain the DMF mixed solution of the penicillin G sulfoxide, and then the DMF mixed solution of the penicillin G sulfoxide is cooled and placed quietly, the penicillin G sulfoxide DMF composite crystal is separated out, and the penicillin G sulfoxide DMF composite crystal is filtered, washed and dried. The penicillin G sulfoxide DMF composite crystal is good in stability, low in water content and does not contain impurities to damage protection for the esterification protective reacti
Bibliography:Application Number: CN20121557522