Synthesis method of 1,1-diphenyl cyclopropane derivative

The invention relates to a synthesis method of a 1,1-diphenyl cyclopropane derivative and discloses a method for preparing a compound IX from a compound VIII via a compound XVI, wherein the compound IX is an important intermediate compound for the preparation of an SGLT2 inhibitor; R1 is selected fr...

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Bibliographic Details
Main Authors ZHAO GUILONG, WANG YULI, WEI QUNCHAO, TANG LIDA, XU WEIREN, ZOU MEIXIANG
Format Patent
LanguageChinese
English
Published 17.04.2013
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a synthesis method of a 1,1-diphenyl cyclopropane derivative and discloses a method for preparing a compound IX from a compound VIII via a compound XVI, wherein the compound IX is an important intermediate compound for the preparation of an SGLT2 inhibitor; R1 is selected from H, F, Cl, Br, I, OR3, SR4, OCF3, CF3, CHF2, CH2F, C1-3 alkyl and C3-5 cycloalkyl; R3 and R4 are selected from C1-3 alkyl independently; R2 is selected from C1-3 alkyl, cyclopropyl and OR5; and R5 is selected from C1-3 alkyl and cyclopropyl.
Bibliography:Application Number: CN2013112246