Vaccine compositions based on sticholysin encapsulated in liposomes

The current invention relates to the field of Biotechnology applied to human health. Here it is described a vaccine vehicle wherein toxins from eukaryotic organisms are encapsulated into multilamellar vesicles obtained by the dehydration-rehydration procedure whose lipidic composition is dipalmitoyl...

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Main Authors PAZOS SANTOS ISABEL FABIOLA, ALVAREZ VALCARCEL CARLOS MANUEL, FERNANDEZ MOLINA LUIS ENRIQUE, VALLE GARAY AISEL, ALONSO BIOSCA MARIA EUGENIA, CANET SANTOS LIEM, CRUZ LEAL YOELYS, MESA PARDILLO CIRCE, TEJUCA MARTINEZ MAYRA, LANIO RUIZ MARIA ELIANA, LUZARDO LORENZO MARIA DEL CARMEN, LABORDE QUINTANA RADY JUDITH
Format Patent
LanguageChinese
English
Published 03.12.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The current invention relates to the field of Biotechnology applied to human health. Here it is described a vaccine vehicle wherein toxins from eukaryotic organisms are encapsulated into multilamellar vesicles obtained by the dehydration-rehydration procedure whose lipidic composition is dipalmitoylphosphatidylcholine: cholesterol in a 1:1 molar ratio for subcutaneous or intramuscular administration. These compositions do not require the use of other adjuvants. The disclosed compositions allow modulation of CTL-specific immune response against one or several antigens co-encapsulated into toxin-containing liposomes. The vaccinal vehicle of the present invention shows advantages over others disclosed by the previous art due to the robustness and functionality of the induced immune response as well as its immunomodulating properties.
Bibliography:Application Number: CN201180033067