Sesquiterpene lactone (1 beta, 10 beta-epoxy-13-alpha-dimethylamino-1,2-propanediol 3-(4)-alkene-6,12-lactone) dimethylamine hydrochloride freeze-drying preparation for injection and preparation method for sesquiterpene lactone (1 beta, 10 beta-epoxy-13-alpha-dimethylamino-1,2-propanediol 3-(4)-alkene-6,12-lactone) dimethylamine hydrochloride freeze-drying preparation

• Main Authors: BAI XIAOXUE, LI XIAOHUA, GUO WENMIN, LIU FENG, ZHOU GUIRONG, LIU CUIYAN
• Format: Patent
• Language: Chinese; English
• Published: 28.11.2012
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a sesquiterpene lactone (1 beta, 10 beta-epoxy-13-alpha-dimethylamino-1,2-propanediol 3-(4)-alkene-6,12-lactone) dimethylamine hydrochloride freeze-drying preparation for injection and a preparation method for the sesquiterpene lactone (1 beta, 10 beta-epoxy-13-alpha-dimethylamino-1,2-propanediol 3-(4)-alkene-6,12-lactone) dimethylamine hydrochloride freeze-drying preparation. The freeze-drying preparation contains sesquiterpene lactone (1 beta, 10 beta-epoxy-13-alpha-dimethylamino-1,2-propanediol 3-(4)-alkene-6,12-lactone) dimethylamine hydrochloride and a pH regulator; and the pH value before freeze-drying is 5.0 to 6.0. Compared with the prior art, the sesquiterpene lactone (1 beta, 10 beta-epoxy-13-alpha-dimethylamino-1,2-propanediol 3-(4)-alkene-6,12-lactone) dimethylamine hydrochloride freeze-drying preparation which is prepared by the method according to a prescription and used for the injection has the advantages that the content of relative substances is reduced obviously, an