Process for the preparation of 4-bromomethyl-[1,1'-biphenyl]-2'-carbonitrile

Process for the preparation of the compounds of the general formula (I) - where in the formula R represents cyano group, -COOR1 or -CONR2R3 group- where R1, R2 and R3 stand for identical or non-identical substituents chosen from the following atom or groups: hydrogen atom, straight or branched C1-7...

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Bibliographic Details
Main Authors HUSZAR CSABA, ARVAI GEZA, HEGEDUS ADRIENN
Format Patent
LanguageChinese
English
Published 21.11.2012
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Process for the preparation of the compounds of the general formula (I) - where in the formula R represents cyano group, -COOR1 or -CONR2R3 group- where R1, R2 and R3 stand for identical or non-identical substituents chosen from the following atom or groups: hydrogen atom, straight or branched C1-7 alkyl group, C3-6 cycloalkyl group; or in one given case a tetrazolyl group substituted with a C1-4 alkyl group or triphenylmethyl group - wherein a compound of the general formula (II) - where the meaning of R is as defined above - is reacted with one of the following reagent pairs as bromine sources: bromate with hydrogen sulfite, or bromate with pyrosulfite, or bromide with percarbonate, or bromide with perborate, in aqueous-organic binary systems, and optionally the resulting compound of the general formula (I) is isolated from the reaction mixture by a method known per se.
Bibliography:Application Number: CN201080065332