Chromanone compound, and preparation method and application thereof
The invention discloses a chromanone compound, and a preparation method and application thereof. The chromanone compound is Tobchromanone A and is separated from aromatic tobacco; the molecular formula is C14H16O4; and the structure is shown in the specification. The preparation method of the chroma...
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Main Authors | , , , , , |
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Format | Patent |
Language | Chinese English |
Published |
14.11.2012
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Subjects | |
Online Access | Get full text |
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Summary: | The invention discloses a chromanone compound, and a preparation method and application thereof. The chromanone compound is Tobchromanone A and is separated from aromatic tobacco; the molecular formula is C14H16O4; and the structure is shown in the specification. The preparation method of the chromanone compound comprises the following steps: crushing an aromatic tobacco sample, performing ultrasonic extraction with 95% ethanol for 3-5 times, merging the extracting solutions, and concentrating under reduced pressure to obtain an extract; and performing primary separation on the extract through silica gel column chromatography, and then performing further separation through high pressure liquid chromatography to obtain the required compound, namely the Tobchromanone A. The compound has a better cytotoxic effect on human neuroblastoma cells (SHSY5Y) with the IC50 value up to 2.8 mu M, and indicates a medium cytotoxic effect on other measured cell strains. |
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Bibliography: | Application Number: CN20121304878 |