Method for preparation of pyridopyrimidine derivatives

Novel 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid derivatives of the general formula in which R represents an alkyl group having 1-12 carbon atoms, which can optionally be substituted by an alkoxycarbonyl group having 1-4 carbon atoms, and furthermore denotes a cycloalkyl group having 3-9 car...

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Bibliographic Details
Main Authors ISTVAN HERMECZ, LELLE VASVARI, JOZSEF KNOLL
Format Patent
LanguageEnglish
Published 04.01.1995
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid derivatives of the general formula in which R represents an alkyl group having 1-12 carbon atoms, which can optionally be substituted by an alkoxycarbonyl group having 1-4 carbon atoms, and furthermore denotes a cycloalkyl group having 3-9 carbon atoms, an adamantyl group or an optionally substituted phenyl group, R represents hydrogen or an alkyl group having 1-4 carbon atoms or R and R together form a chain of the formula -(CH2)n- in which n represents 4, 5 or 6, R represents hydrogen, halogen or an alkyl group having 1-4 carbon atoms and R represents hydrogen or an alkyl group having 1-4 carbon atoms, while the meaning of m is 0 or 1. The compounds have gastroprotective activity. They are prepared in analogy to known processes.
Bibliography:Application Number: CN19891002006