Method for synthesizing curcumin through catalysis of alumina supported potassium fluoride solid base

• Main Authors: HOU XIULIANG, GAO LIHONG, YUAN SHUNFU, GAO HAIYAN, HUANG JIEFANG, WANG HAIJUN, YUE JUAN, CAI LI
• Format: Patent
• Language: Chinese; English
• Published: 03.10.2012
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention provides a green synthetic method of curcumin, which comprises the steps as follows: alumina supported potassium fluoride solid base is taken as a catalyst, and boric anhydride is used for protecting active methylene groups of diacetone; diacetone and 4-hydroxyl-3-methoxy-benzaldehyde are dissolved in a polar aprotic solvent, and condensation reaction is performed; a hydrophobic organic solvent is added, the catalyst is filtered out and recovered for reutilization; dilute hydrochloric acid is added for hydrolysis; liquid separation and washing are carried out; the solvent is removed through rotary evaporation; and recrystallization and drying are carried out so as to obtain curcumin. The green synthetic method has the advantages as follows: the operation of the synthetic method is simple, the reaction yield coefficient is high, the product purity is high, and zero environmental contamination can be achieved; the catalyst is convenient to prepare, is economical to buy, achieves good stability, an