N-piperidinyl acetamide derivatives as calcium channel blockers

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity, are disclosed. Specifically, a series of compounds which are N-piperidinyl acetamide derivatives as shown in formula (1) are disclosed...

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Bibliographic Details
Main Authors CHAKKA NAGASREE, TAN JASON, KAUL RAMESH, ZHOU YUANXI, DING YANBING, GRIMWOOD MIKE, PAJOUHESH HASSAN, ZHU YONGBAO, ZHANG LINGYUN
Format Patent
LanguageEnglish
Published 22.07.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity, are disclosed. Specifically, a series of compounds which are N-piperidinyl acetamide derivatives as shown in formula (1) are disclosed as calcium ion channel activating modulators. Compositions comprising these compounds and the use of these compounds in the treatment or prevention of conditions such as epilepsy are also disclosed.
Bibliography:Application Number: CN200980129679