Endophytic fungi ES026 of huperzia serrata capable of generating huperzine a
The invention belongs to the technical fields of medicinal plants and agricultural microorganism and particularly relates to an endophytic fungi which is separated from a medicinal plant huperzia serrata, can generate huperzine a or analogues, and can be used in mass production of the huperzine a or...
Saved in:
Main Authors | , , , , |
---|---|
Format | Patent |
Language | Chinese English |
Published |
05.09.2012
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The invention belongs to the technical fields of medicinal plants and agricultural microorganism and particularly relates to an endophytic fungi which is separated from a medicinal plant huperzia serrata, can generate huperzine a or analogues, and can be used in mass production of the huperzine a or analogues. The separated endophytic fungi ES026 is identified as colletotrichum gloeosporioides bymolecular biology and morphology, and the strain has been preserved in China Center For Type Culture Collection (CCTCC), with the preservation number of CCTCC NO: M2011046. The endophytic fungi is significantly characterized in that after liquid fermentation, the strain can generate an active substance with reversibility which can inhibit acetylcholinesterase, and high-performance liquid chromatography and mass spectrum analysis shows that the compound is huperzine a (HupA), thus a new medicinal herb source for treating alzheimer's disease is provided. |
---|---|
Bibliography: | Application Number: CN2011150525 |