Preparation method of high-activity chiral catalyst (spiroborate)

• Main Authors: SUN GUOSONG, HUANG PING, MU YUNLING, HUANG KERUN, YUAN FANGAI, WEI ZHIMING, TAN LANHUA
• Format: Patent
• Language: Chinese; English
• Published: 18.07.2012
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL METHODS OF ORGANIC CHEMISTRY; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention discloses a preparation method of high-activity chiral catalyst (spiroborate) which is mainly used for asymmetrically catalyzing and reducing prochiral ketone and oxime ether. According to the chiral spiroborate preparation process disclosed by the invention, carboxylic ester is taken as a solvent, a mixed solution of sinistrogyration Alpha- alkamine, low-carbon alkyl vicinal diol or diphenol and borate is subjected to backflow stirring and complexing so as to obtain spiroborate, wherein the reaction can be carried out without the protection of inert gas, and a toxic solvent (toluene) is replace with a green solvent (low-carbon esters), so that the safety of products can be improved. The catalytic performance of the catalyst obtained under the process condition can be improved, and the stability of the catalyst is improved, the chiral spiroborate being less than 10% in the equivalent weight is adopted for catalyzing and reducing borane to obtain corresponding chiral aromatic alcohol and chiral p