Method for improving target effect of receptor targeting preparation based on folic acid compounds

The invention relates to the field of medicinal preparations and particularly relates to a method for improving an active targeting effect of an active targeting preparation based on folic acid compounds by increasing distribution of targeting groups, namely folic acid compound groups, of the active...

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Bibliographic Details
Main Authors PING QINENG, XIAO YANYU, ZONG LI, SHI YONGPING
Format Patent
LanguageChinese
English
Published 18.07.2012
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to the field of medicinal preparations and particularly relates to a method for improving an active targeting effect of an active targeting preparation based on folic acid compounds by increasing distribution of targeting groups, namely folic acid compound groups, of the active targeting preparation in external water phase. The method is characterized in that the key difference between the method and the conventional preparation method is that normal water, osmotic-pressure regulator solution or neutral buffer saline solution does not serve as the water phase, but alkalescence solution with pH being 7.5-10.0 serves as the water phase. The active targeting effect of the receptor targeting preparation prepared by the method can be improved.
Bibliography:Application Number: CN2012146204