9(R)-hydrogenation-1-deoxidation taxol derivative modified by C4 and preparation method thereof

The invention relates to a 9(R)-hydrogenation-1-deoxidation taxol derivative modified by C4 and a preparation method thereof. The structural formula of the derivative is shown in a specification. The 9(R)-hydrogenation-1-deoxidation taxol derivative modified by C4, which is prepared by adopting the...

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Bibliographic Details
Main Authors LIN HAIXIA, LV XIASHI, CUI YONGMEI, YU JIE, YUAN TIANHAI
Format Patent
LanguageChinese
English
Published 11.07.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a 9(R)-hydrogenation-1-deoxidation taxol derivative modified by C4 and a preparation method thereof. The structural formula of the derivative is shown in a specification. The 9(R)-hydrogenation-1-deoxidation taxol derivative modified by C4, which is prepared by adopting the method disclosed by the invention, has the anti-tumor biological activity of natural taxol, and has a certain application prospect in the aspects of improving the water-solubility of the natural taxol, reducing multidrug resistance plus the toxic and side effects of the natural taxol. A raw mateiral 1-dehydroxy baccatin VI used in the method disclosed by the invention has high content in taxus mairei and is easy to separate; the operation is simple and convenient; and the selectivity is good and the yield is high.
Bibliography:Application Number: CN20111440820