Analogues of insulin-like growth factor-1 (igf-1) having amino acid substitution at position 59

The present invention relates to novel analogues of insulin-like growth factor-1 (IGF-1), pharmaceutical compositions containing said analogues, and the use of said analogues for treatment of IGF-1-receptor mediated conditions, such as short stature, diabetes therapy, neurodegenerative disease treat...

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Bibliographic Details
Main Authors UFRET MARIA L, ZHANG JUNDONG, COMSTOCK JEANNE MARY, DONG ZHENG XIN, PRAIRIE NICHOLAS C, ROTHMAN DEBORAH
Format Patent
LanguageEnglish
Published 18.03.2015
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to novel analogues of insulin-like growth factor-1 (IGF-1), pharmaceutical compositions containing said analogues, and the use of said analogues for treatment of IGF-1-receptor mediated conditions, such as short stature, diabetes therapy, neurodegenerative disease treatment, and cartilage repair. More particularly, the present invention relates to novel analogues of IGF-1 having an amino acid substitution at position 59, e.g., (Asn59)hIGF-1(1-70)-OH (SEQ ID NO:1), and other substitution(s) as defined herein.
Bibliography:Application Number: CN201080041981