Tumor-targeted carrier material as well as preparation method and application thereof

• Main Authors: WANG DEQIAN, LIU RUIGANG, HUANG YONG
• Format: Patent
• Language: Chinese; English
• Published: 05.10.2011
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention discloses a tumor-targeted carrier material as well as a preparation method and application thereof. The carrier material has a structural formula represented by the formula II. The preparation method comprises the following steps of: in an aqueous solution, initiating glucan to graft onto poly N-(2-hydroxypropyl)methylacrylamide and polymethacryl amino acid by using K2S2O8/NaHSO3 to introduce PHPMA capable of prolonging blood circulation time and reactive carboxylic groups to the main chain of the glucan, controlling added mass ratio of reacting monomers to obtain a glucan-based graft polymer with different grafting percents, amidating to graft onto a proper quantity of tyrosine for 125I marking, and carrying out mouse experiments. The carrier material has longer blood circulation time. Because of the longer blood circulation time and larger component content in blood, the glucan graft polymer targeted radiotherapy carrier prepared by using the preparation method can be widely applied to target