2,4-diaminopyrimidine compound

Disclosed is a compound which is useful as a medicinal agent having a PKC[Theta] inhibition activity, particularly as an active ingredient for a pharmaceutical composition for inhibiting acute rejection occurring in transplantation. Studies have been made on compounds having a PKC[Theta] inhibition...

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Main Authors CHIDA NOBORU, TANAKA AKIRA, NAGASHIMA SHINYA, MUKOYOSHI KOICHIRO, MAEDA JUN, KUNIKAWA SHIGEKI, TAKASUNA YUJI
Format Patent
LanguageChinese
English
Published 27.07.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed is a compound which is useful as a medicinal agent having a PKC[Theta] inhibition activity, particularly as an active ingredient for a pharmaceutical composition for inhibiting acute rejection occurring in transplantation. Studies have been made on compounds having a PKC[Theta] inhibition activity. As a result, it is confirmed that a compound characterized by having a structure such as an aralkyl on an amino group at position-2 and also having a structure such as an adamantyl alkyl on an amino group at position-4 in 2,4-diaminopyrimidine or a salt of the compound has an excellent PKC[Theta] inhibition activity. The 2,4-diaminopyrimidine compound can be used as a PKC[Theta] inhibitor or an inhibitor of acute rejection occurring in transplantation.
Bibliography:Application Number: CN200980134176