Improvements to mass spectrometry

A matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) apparatus and a method comprise a laser (100) and a multimode optical fiber (101) to deliver a laser beam to a MADLI ion source (104). A vibration coupling (109) is provided at a region along the length of optical fi...

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Bibliographic Details
Main Authors OAKES KEITH, ATKINSON SALLY, CLENCH MALCOLM
Format Patent
LanguageChinese
English
Published 13.07.2011
Subjects
BASIC ELECTRIC ELEMENTS
ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
ELECTRICITY
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Summary:A matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) apparatus and a method comprise a laser (100) and a multimode optical fiber (101) to deliver a laser beam to a MADLI ion source (104). A vibration coupling (109) is provided at a region along the length of optical fiber (101) to impart an oscillatory vibrational motion at the optical fibre (101) to move the irradiation intensity maxima at the sample (104) to increase the effective irradiation surface area. The present apparatus and method provide increased imaging sensitivity and a corresponding reduction in data acquisition times.
Bibliography:Application Number: CN200980129598