Surface biological functionalization method for hydrophobic medical high polymer materials
A major part of medical high polymer materials are hydrophobic and do not have bioactivity, so it is very necessary to perform the biological functionalization modification of the surface of the medical high polymer materials so as to improve the biological compatibility of the materials. By taking...
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Main Authors | , , |
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Format | Patent |
Language | Chinese English |
Published |
29.06.2011
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Subjects | |
Online Access | Get full text |
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Summary: | A major part of medical high polymer materials are hydrophobic and do not have bioactivity, so it is very necessary to perform the biological functionalization modification of the surface of the medical high polymer materials so as to improve the biological compatibility of the materials. By taking poly(hydroxybutyrate-hydroxyvalerate) (PHBV) which is a non-immunogenic biological material for example, the inventor provides the surface biological functionalization method for the hydrophobic medical high polymer materials. Through ammonia plasma treatment or modifying dopamine, amino can be introduced onto the surface of the PHBV, and consequently the surface of the PHBV can be modified with polyethylene glycol molecules (NHS-PEG-MAL) with different functional groups at terminal and short peptides containing arginine-glycine-aspatic acid (RGD). In-vitro cell experiments and protein absorption experiments prove that the biological compatibility of the modified PHBV is improved obviously. The introduced RGD short |
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Bibliography: | Application Number: CN2011137602 |