Compound pharmaceutical composition for improving oral bioavailability of taxol and application thereof

• Main Authors: GU LIANQUAN, BI HUICHANG, JIN JING, HUANG MIN, CAI DAKE
• Format: Patent
• Language: Chinese; English
• Published: 15.06.2011
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a compound pharmaceutical composition for improving oral bioavailability of taxol and application thereof. The invention also discloses a pharmaceutical composition containing the compound pharmaceutical composition and a taxol monomeric compound. The compound pharmaceutical composition provided by the invention can be used for improving the oral bioavailability of the taxol and can improve the anticancer effect of the taxol when used for preparing anticancer drugs. In the compound pharmaceutical composition provided by the invention, the taxol is the main anticancer component, and the traditional Chinese medicine extract monomeric compound improves the oral bioavailability and the anticancer effect of the taxol by inhibiting the first-pass effect of the taxol. Shown by experimental study, the compound pharmaceutical composition provided by the invention can be prepared into an oral medicament to improve the blood concentration and the anticancer effect of the taxol after oral administ