Pegylated insulin lispro compounds

The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized b...

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Main Authors BEALS JOHN MICHAEL, LI SHUN, CUTLER GORDON BUTLER, HANSEN RYAN JOHN, SHIRANI SHAHRIAR, DOYLE BRANDON, ZHANG LIANSHAN
Format Patent
LanguageChinese
English
Published 18.05.2011
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized by pharmacokinetic, pharmacodynamic, and/or activity peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses.
Bibliography:Application Number: CN200980122164