Theasapogenol derivative with antibacterial effect as well as preparation method and application thereof

• Main Authors: LUO YUETING, YE YONG
• Format: Patent
• Language: Chinese; English
• Published: 18.07.2012
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS

The invention discloses a theasapogenol derivative with an antibacterial effect as well as a preparation method and application thereof. The theasapogenol derivative with an antibacterial effect is 28-(4-dioxolane-1-ethoxybutoxy)-tea sapogenol and is prepared by the following steps of: making triphenylchloromethane react with theasapogenol for protecting a primary hydroxyl on theasapogenol C28; making acetic anhydride react with theasapogenol for protecting a secondary hydroxyl on the theasapogenol; adding a triphenylmethyl removing protective agent, removing triphenylmethyl and leading the primary hydroxyl on the theasapogenol C28 to protect; adding 4-dioxolame-1,1-diethyloxy butane for reacting and connecting with the theasapogenol; and finally, adding an acetyl removing protective agent, removing the acetyl on the theasapogenol and crystallizing to obtain the theasapogenol derivative shown as the formula I. The antibacterial activity of the theasapogenol derivative of the inventionis obviously improved, an