Preparation method and application of silicon rubber/collagen-based porous skin scaffold material

• Main Authors: ZHOU ZHIHUA, NIE HUARONG, SHEN XINGXING, HU KUIKUI, CHEN YIWANG
• Format: Patent
• Language: Chinese; English
• Published: 27.04.2011
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

The invention relates to a preparation method and application of a silicon rubber/collagen-based porous skin scaffold material. The preparation method comprises the following steps of: (1) putting an organic silicon film into a plasma treatment instrument, and introducing a polar group into the surface of silicon rubber; (2) preparing collagen solution or mixed solution of collagen and other biomacromolecules at certain concentration, coating the solution on the surface of a silicon rubber film obtained in the step (1), and extracting a solvent by using a freeze dryer; (3) soaking a silicon rubber/collagen-based composite scaffold obtained in the step (2) in a dehydrating agent-containing mixed solvent of ethanol and water, reacting for 6 to 12 hours at room temperature, and soaking and washing by using a large amount of deionized water; and (4) putting a scaffold obtained in the step (3) into the freeze dryer again to extract absorbed water. The silicon rubber/collagen-based composite porous material prepare