Compound with anti-HCV activity and application thereof

• Main Authors: WANG SHUN, LUAN WEILI
• Format: Patent
• Language: Chinese; English
• Published: 29.12.2010
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a compound shown in the general formula (I) or pharmaceutically acceptable salt or hydrates thereof. In the general formula (I), Ar is substituted or unsubstituted acryl or heteroaryl; Z is selected from N and substituted or unsubstituted C; R1 and R2 are selected from the substituted or unsubstituted substitutes in the following groups independently: -CH2Ra, -NH-S(O)2Ra, -CH2-NH-S(O)2Ra, -S(O)2Ra, -C(O)-NH-Ra, -C(O)-NH-CH2Ra, -NH-C(O)-Ra, -NH-C(O)-Rb, -C(O)O-Ra, -C(O)-O-Rb, -ORa, -C(O)-Ra, -C(O)-Rb, hydrogen atoms, C1-C10 alkyl, phenyl, five-six membered heteroaryl, benzo-five-six membered naphthenic base or hetero-naphthenic base and eight-ten membered bicyclic heteroaryl; or R1 and R2 are combined to form C3-C14 single, two or three cycle containing heteroatoms; Ra is randomly selected from substituted or unsubstituted substitutes in the following groups: hetero-naphthenic base, phenyl and five-six membered heteroaryl; Rb is substituted or unsubstituted C1-C6 alkyl; and R is selecte