Pyrimidyl cyclopentanes as akt protein kinase inhibitors

The present invention provides compounds of Formula I , including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for...

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Bibliographic Details
Main Authors SPENCER KEITH L, MITCHELL IAN S, XU RUI, XIAO DENGMING, CHABOT CHRISTINE, BENCSIK JOSEF R, LIANG JUN, SAFINA BRIAN S, KALLAN NICHOLAS C, BLAKE JAMES F
Format Patent
LanguageChinese
English
Published 05.06.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds of Formula I , including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Bibliography:Application Number: CN200880105870