Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof

• Main Authors: JAMES ADRIAN B, MACDONALD PETER S, GLENN GREGORY M, FRERICHS DAVID, MOHRI LIONEL, INOUYE MATTHEW D, STEEVES CHARLES F. III, ROMERO GINA L, EPPERSON DIANE E, MASON BRIAN J, LISTER ROBERT I, LUBENSKY DAVID A, VILLAR CHRISTINA P, MCELHANEY CHRISTINE W, KAPLAN JONATHAN I, ELLINGSWORTH LARRY R, HENNINGSGAARD AARON A, LAI JOHN W, HAMER MERVYN L, DOERKSEN KYLE J, YU JIANMEI, PIGLIACAMPO ANTHONY C, MADSEN SALLY H
• Format: Patent
• Language: Chinese; English
• Published: 15.12.2010
• Subjects: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; DIAGNOSIS; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; MEDICAL OR VETERINARY SCIENCE; SURGERY

The invention provides devices for the disruption of one or more layers of skin and methods of their use to administer therapeutic agents, e.g., antigens or drugs. The devices are designed to disrupt a defined area of skin. The defined area can approximate the area that a patch or other suitable vehicle for therapeutic agent, e.g., drug or vaccine, delivery is designed to contact. Exemplary devices employ a mask to define the area to be disrupted. Other devices disrupt a defined area by rotating in place. For devices that employ a mask that is secured to the skin, the invention provides methods of disrupting the stratum corneum by first securing the mask to the skin and then disrupting the skin. For rotating devices, the disrupting member is simply placed against the skin and actuated to effect disruption.