Method for preparing bioactive spherical titanium dioxide nanometer points on surface of medical metal

• Main Authors: LIU XIAOHUA, JIAN XUEMEI, MA PIANPIAN, CHENG KUI, WENG WENJIAN, REN CHANGBAO, HONG YI
• Format: Patent
• Language: Chinese; English
• Published: 21.12.2011
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMICAL SURFACE TREATMENT; CHEMISTRY; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATIONOR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY IONIMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; COATING MATERIAL WITH METALLIC MATERIAL; COATING METALLIC MATERIAL; DIFFUSION TREATMENT OF METALLIC MATERIAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION INGENERAL; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THESURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION

The invention discloses a method for preparing bioactive spherical titanium dioxide nanometer points on the surface of a medical metal. Based on the sol-gel precursor of titanium, the method comprises the following steps of: adding macromolecule polymer additive into the sol-gel precursor of the titanium to lead the precursor to perform the spontaneous phase splitting after forming a sol film on the surface of the medical metal; and heat treating to obtain the spherical titanium dioxide nanometer points which are combined with the surface of the medical metal and have bioactivity. By adjusting the concentration of titanium source in the precursor solution, the concentration of phase-splitting agent, the rotatable coating speed and time or the dipping and pulling speed and time, the methodcan control the size and the concentration of the spherical titanium dioxide nanometer points prepared on the surface of the metal, and improve the surface bioactivity and the cell compatibility of the bio-medical metal.