Method for producing precursors for l-3,4-dihydroxy-6-[18f]fluorophenylalanine and 2-[18f]fluoro-l-tyrosine and the a-methylated derivatives thereof, said precursor, and a method for producing l-3,4-dihydroxy-6-[18f]fluorophenylalanine and 2-[18f]fluoro-l-tyrosine and the a-methylated derivatives thereof from the precursor

The invention relates to a method for producing precursors for L-3,4-dihydroxy-6-[18F]fluorophenylalanine and 2-[18F]fluoro-L-tyrosine and the a-methylated derivatives thereof, said precursor, and a method for producing L-3,4-dihydroxy-6-[18F]fluorophenylalanine and 2-[18F]fluoro-L-tyrosine and the...

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Bibliographic Details
Main Authors COENEN HEINRICH HUBERT, ERMERT JOHANNES, WAGNER FRANZISKA
Format Patent
LanguageChinese
English
Published 17.11.2010
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a method for producing precursors for L-3,4-dihydroxy-6-[18F]fluorophenylalanine and 2-[18F]fluoro-L-tyrosine and the a-methylated derivatives thereof, said precursor, and a method for producing L-3,4-dihydroxy-6-[18F]fluorophenylalanine and 2-[18F]fluoro-L-tyrosine and the a-methylated derivatives thereof from the precursor. According to the invention, a compound of formula (3) is used to enable an automated synthesis of L-3,4-dihydroxy-6-[18F]fluorophenylalanine and 2-[18F]fluoro-L-tyrosine. The enantiomer purity of the product amounts to = 98%.
Bibliography:Application Number: CN200880119256