Novel piperazinyl pyridazine compounds

• Main Authors: YANG LING, HU WENHUI, LIAO SHENGRONG, XU HONGJIANG
• Format: Patent
• Language: Chinese; English
• Published: 05.09.2012
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to novel piperazinyl pyridazine compounds in a formula I or salts thereof, a preparation method thereof and use thereof as nervous inflammation inhibitors in treating or preventing neurodegenerative diseases such as senile dementia, Parkinson's disease, cognitive impairment and the like or treating diseases such as mental disorder, epilepsy, convulsions, stroke and the like.The compounds have the advantages of simple preparation process, readily available raw materials and suitability for industrial large-scale production. In addition, through the verification of in-vitro experiments, the compounds have the effect of inhibiting BV2 from secreting IL-1 beta efficiently, and the effect is superior to that of positive medicaments; and simultaneously, the compound have no inhibiting effect on the secretion of the IL-1 beta by C6, and thus the compounds have high safety.