Novel piperazinyl pyridazine compounds

The invention relates to novel piperazinyl pyridazine compounds in a formula I or salts thereof, a preparation method thereof and use thereof as nervous inflammation inhibitors in treating or preventing neurodegenerative diseases such as senile dementia, Parkinson's disease, cognitive impairmen...

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Bibliographic Details
Main Authors YANG LING, HU WENHUI, LIAO SHENGRONG, XU HONGJIANG
Format Patent
LanguageChinese
English
Published 05.09.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to novel piperazinyl pyridazine compounds in a formula I or salts thereof, a preparation method thereof and use thereof as nervous inflammation inhibitors in treating or preventing neurodegenerative diseases such as senile dementia, Parkinson's disease, cognitive impairment and the like or treating diseases such as mental disorder, epilepsy, convulsions, stroke and the like.The compounds have the advantages of simple preparation process, readily available raw materials and suitability for industrial large-scale production. In addition, through the verification of in-vitro experiments, the compounds have the effect of inhibiting BV2 from secreting IL-1 beta efficiently, and the effect is superior to that of positive medicaments; and simultaneously, the compound have no inhibiting effect on the secretion of the IL-1 beta by C6, and thus the compounds have high safety.
Bibliography:Application Number: CN2009131106