Ligustrazine nanoparticle, preparation method and pharmaceutical application thereof

The invention relates to a ligustrazine nanoparticle, a preparation method and pharmaceutical application thereof. The preparation method comprises the following steps of: dissolving polylactic acid in acetone to form a polylactic acid acetone solution; then dissolving ligustrazine in the polylactic...

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Bibliographic Details
Main Authors MAO CHUNQIN, BIAN YAOYAO, BI LEI, LI LIN, LU TULIN, WANG XIAOWEN, LI ZHENGYAN, ZENG LI, LU MIN
Format Patent
LanguageChinese
English
Published 08.09.2010
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a ligustrazine nanoparticle, a preparation method and pharmaceutical application thereof. The preparation method comprises the following steps of: dissolving polylactic acid in acetone to form a polylactic acid acetone solution; then dissolving ligustrazine in the polylactic acid acetone solution to form an oil phase; adding the oil phase to a surface active agent-contained aqueous phase solution which is at the constant temperature of 20-50 DEG C; after the two phases are mixed, stirring for 50-90min at the temperature of 20-50 DEG C to make acetone volatilize to obtain a ligustrazine nanoparticle solution. The invention has simple process, mild reaction condition, even manufactured particle size and narrow distribution. Moreover, adopted auxiliary materials are biodegradable and have good biocompatibility, no toxic or side effects and sufficient market raw materials. Wrapped in the nanoparticle, ligustrazine can stably and slowly release, can effectively prevent and treat postoperat
Bibliography:Application Number: CN20101179512