Novel method for the synthesis of (7-methoxy-l-naphthyl)acetonitrile and application in the synthesis of agomelatine

Process for industrial synthesizing of (7-methoxy-naphthalen-1-yl)-acetonitrile (I) comprises: reacting 7-methoxy-1-naphthoic acid (III) with a reducing agent to give (7-methoxy-naphthalen-1-yl)-methanol compound (IV); and reacting (IV) of which the hydroxyl group is transformed, with a cyanation re...

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Bibliographic Details
Main Authors HERMET JEAN-PAUL, LECOUVE JEAN-PIERRE, DUBUFFET THIERRY
Format Patent
LanguageChinese
English
Published 18.09.2013
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Process for industrial synthesizing of (7-methoxy-naphthalen-1-yl)-acetonitrile (I) comprises: reacting 7-methoxy-1-naphthoic acid (III) with a reducing agent to give (7-methoxy-naphthalen-1-yl)-methanol compound (IV); and reacting (IV) of which the hydroxyl group is transformed, with a cyanation reagent to obtain (I), which is isolated in solid form. An independent claim is included for a process of synthesizing agomelatin from (I), comprising subjecting (I) for reduction followed by coupling with acetic anhydride.
Bibliography:Application Number: CN200880101738