Method for screening malignant ovarian tumor markers from blood serum metabolic profiling

• Main Authors: ZHANG XIAOYAN, ZHAO SUMIN, LU XIN, WU XIAOHUA, XU CONGJIAN, XU GUOWANG, CAO RUI, WAN XIAOPING, CHEN JING
• Format: Patent
• Language: Chinese; English
• Published: 07.07.2010
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention discloses a method for screening malignant ovarian tumor markers according to blood serum metabolic profiling. In the method, the Ultra Performance Liquid Chromatography-mass spectrometry technology is employed to analyze blood serum to obtain blood serum metabolic profiling; then the multivariate statistics method is employed to analyze data concerning malignant ovarian tumor and blood serum metabolic profiling of healthy people, so as to screen maker spectrums. The screening method of the invention features good repeatability and good forecasting property of the screened markers. Proven by discriminant classification analysis, the screening method enjoys an average forecasting precision rate of 90.90% and a positive relevance ratio of 82.65%.The maker spectrum covering multiple compounds can be obtained in a single analysis, which indicates that the marker is suitable for high flux analysis and enjoys the prospect of being promoted to large-scale sample screening and clinical application.