Insulin slow release micron sphere composition and preparation method thereof

The invention provides an insulin slow release micron sphere composition and a preparation method thereof, belonging to the field of biotechnology pharmacy. The composition has the following components by weight percent: 50-99.8% of polylactic acid-glycollic acid, polylactic acid or polycaprolactone...

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Bibliographic Details
Main Authors YUAN WEIEN, WU FEI, LIU CHENGRONG, JIN TUO, CHEN WEIJUAN
Format Patent
LanguageChinese
English
Published 09.06.2010
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides an insulin slow release micron sphere composition and a preparation method thereof, belonging to the field of biotechnology pharmacy. The composition has the following components by weight percent: 50-99.8% of polylactic acid-glycollic acid, polylactic acid or polycaprolactone, and 0.2-50% of insulin nano sphere composition. The preparation method comprises two steps: 1) preparation of insulin nano sphere composition; and 2) preparation of insulin slow release micron sphere composition. The invention overcomes the defects that spherical micro nanospheres can not be prepared by the prior art, the stability of the micro nanospheres in high polymer slow and controlled release material can not be realized, the entrapment rate is low, S/O/O is in serious burst, and environment pollution is caused. The micron sphere prepared by the method in the invention has controllable particle size, no environment pollution, smooth and rounding surface and structured particles without adhesion, the partic
Bibliography:Application Number: CN20091312647