Preparation method and application of 3'8''-bis-apigenin type bis-flavonoid

The invention discloses a preparation method and application of 3'8''-bis-apigenin type bis-flavonoid. The preparation method of the compound comprises the following steps of: hot refluxing and extracting coarse powders of Taxus cuspidatea twigs and leaves by using ethanol to obtain t...

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Bibliographic Details
Main Authors LI YANPING, GU LIANQUAN, GU QIONG, HUANG ZHISHU, OU TIANMIAO
Format Patent
LanguageChinese
English
Published 30.05.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses a preparation method and application of 3'8''-bis-apigenin type bis-flavonoid. The preparation method of the compound comprises the following steps of: hot refluxing and extracting coarse powders of Taxus cuspidatea twigs and leaves by using ethanol to obtain total extract; and performing reversed phase and normal phase column chromatography, gel and recrystallization and separation on the total extract to obtain the 3'8''-bis-apigenin type bis-flavonoid. The 3'8''-bis-apigenin type bis-flavonoid is used for preparing medicaments for inhibiting formation of senile plaques or treating an Alzheimer disease, can effectively reduce the generation of Beta amyloid, also depolymerizes the aggregated Beta amyloid, has no toxic effect on cells, and also can stimulate growthof cells at a high concentration; and the preparation method has simple process and high yield.
Bibliography:Application Number: CN20091193990