Substituted biphenyl carboxylic acids and derivatives thereof

The present invention relates to compounds having the general formula (I) with the definitions of X,Y and A given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of ³-...

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Main Authors WILSON FRANCIS, TAYLOR JESS, BURCKHARDT SVENJA, HERNADEZ-PERNI REMEDIOS, REID ALISON, SUNOSE MIHIRO, CANSFIELD ANDREW, HARRISON RICHARD JOHN, BOUSSARD CYRILLE, HO CHIH YUNG, ZHANG YAN, MAJOR JEREMY, LEFORMAL ADELINE, SMELT KATHRYN, READER VALERIE
Format Patent
LanguageChinese
English
Published 14.05.2014
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to compounds having the general formula (I) with the definitions of X,Y and A given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of ³-secretase activity. wherein A is O, NH, S; X is a bond or a group -CR 5 R 6 Y is a carboxy group -C(O)OH or a substituted or unsubstituted tetrazole group; and/or a salt or ester thereof.
Bibliography:Application Number: CN200780018586