Tetrahydroisoquinolin-1-one derivative or salt thereof

To provide a compound which can be used as a medicinal agent, particularly a therapeutic agent for irritable bowel syndrome (IBS). ¢MEANS FOR SOLVING PROBLEMS! It is found that a tetrahydroisoquinolin-1-one derivative having an amide group at position-4 or a pharmaceutically acceptable salt thereof...

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Main Authors TAKUWA TOMOFUMI, ISHIHARA TSUKASA, MAENO KYOICHI, ISHIKAWA NORIKO, SHIMIZU TAKAFUMI, SEKI NORIO, SHIMADA ITSURO, HISAMICHI HIROYUKI
Format Patent
LanguageChinese
English
Published 10.03.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:To provide a compound which can be used as a medicinal agent, particularly a therapeutic agent for irritable bowel syndrome (IBS). ¢MEANS FOR SOLVING PROBLEMS! It is found that a tetrahydroisoquinolin-1-one derivative having an amide group at position-4 or a pharmaceutically acceptable salt thereof has an excellent antagonistic activity on a bombesin-2 (BB2) receptor. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on stool abnormality. Therefore, the tetrahydroisoquinolin-1-one derivative is useful as a therapeutic agent for a disease associated with a BB2receptor, particularly IBS.
Bibliography:Application Number: CN200880013953