Fluorescence-based assay for detecting compounds for modulating the sodium-calcium exchanger (NCX) in 'forward mode'

Carriers are an up-and-coming target family with enormous potential and offer commercial and scientific possibilities. The sodium/calcium exchanger is an important mechanism for the removal of Ca<2+> from various cells. In the heart, said sodium/calcium exchanger extrudes Ca<2+>, which h...

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Bibliographic Details
Main Authors VOLLERT HENNING, GEIBEL SVEN, HUG MARTIN, LICHER THOMAS
Format Patent
LanguageChinese
English
Published 27.01.2010
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:Carriers are an up-and-coming target family with enormous potential and offer commercial and scientific possibilities. The sodium/calcium exchanger is an important mechanism for the removal of Ca<2+> from various cells. In the heart, said sodium/calcium exchanger extrudes Ca<2+>, which has entered through Ca<2+> channels for the initiation of contractions, while Na<+> enters the heart cell. It is of considerable interest to identify compounds that modulate the activity of the sodium-calcium exchanger. The present invention relates to a fluorescence-based assay for the detection of compounds for modulating the NCX in 'forward mode'. The invention further relates to a parts set comprising cells that express NCX and to the use of said parts set for testing a compound for activity as an agonist or antagonist of NCX.
Bibliography:Application Number: CN200880008156