Sulfonamide derivative

• Main Authors: KAWASAKI KOH, YAMADA RINTARO, SETO MINORU, MATSUBARA KOKI, IESATO ATSUSHI, OOMURA AKIHUMI
• Format: Patent
• Language: Chinese; English
• Published: 06.01.2010
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Disclosed is a compound represented by the formula (1) below having a strong Rho kinase inhibitory activity, a salt thereof or a derivative of any of them as a prodrug. In the formula (1) below, A represents a nitrogen-containing saturated ring; m represents a number of 0-2; n represents a number of 1-4; G represents a hydrogen atom, a chlorine atom, a hydroxy group, an alkoxy group or an amino group; G represents a halogen atom, a hydroxy group, a cyano group, a carboxy group, an alkyl group, an alkenyl group or the like; G represents a hydrogen atom, a halogen atom, a hydroxy group, a cyano group, a carboxy group, an alkyl group, an alkenyl group or the like; Y represents a single bond or -C(R )(R )- (wherein R and R represent a hydrogen atom or alkyl group, or alternatively they combine together to form a saturated hydrocarbon ring group); G represents a hydroxy group (provided that Y is a single bond) or -N(R )(R ) (wherein R and R represent a hydrogen atom, an alkyl group, an aralkyl group, an alkenyl gr