Haplotype of tumor metastatic suppressor gene HTPAP as well as construction method and application thereof

• Main Authors: YE QINGHAI, TANG ZHAOYOU, JIA HULIANG, REN NING, ZHOU HAIJUN, QIN LUNXIU, SUN HAIJING, WU JINCAI
• Format: Patent
• Language: Chinese; English
• Published: 30.09.2009
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention relates to a haplotype of a tumor metastatic suppressor gene HTPAP as well as a construction method and an application thereof, belonging to the field of gene engineering. Through the SNP examination and the analysis of a patient with liver cancer, the invention constructs the haplotype of the HTPAP with the following structure: C-A-T-C-A, T-G-G-G-G, C-G-T-C-A, T-A-G-G-G, C-A-G-C-A, T-A-G-G-A, C-A-T-G-A, T-A-T-C-A, T-A-G-C-G, C-A-T-G-G or T-G-T-C-G. The haplotype can provide a guide for predicting the metastasis and the recurrence after a liver cancer operation, is simple, convenient and practical and can be used for evaluating the patient with liver cancer after prognosis and taking an integrated method to intervene in time so as to improve the long-dated survival rate of the patient, and providing the reference for improving the prognosis; and the haplotype can be combined with other molecular indexes, , so as to provide a new trial box for the diagnoses of the liver cancer recurrence and the