3 -amino- pyridine derivatives for the treatment of metabolic disorders

The picsenl invention provides novel compounds represented by the general formula (I): wherein Ar is a quinoline or isoquinoline moiety which is substituted or unsubstituted; B is -O. -S-. or -NH-: R1 is hydrogen or S(O)2R4: R2 is S(O)2R4. C(O)OR5. or C(O)(CH2)n-C(O)OR6: R3 is halogen, cyano, C(O)OR...

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Main Authors PADIYA KAMLESH JYOTINDRA, KHAN TAJ USMAN, KULKARNI RHUSHIKESH ARUN, BAJARE SWAPNIL RAMESH, MARITA ROSALIND ADAIKALASAMY, DEKA NABAJYOTI, HARIHARAN SIVARAMAKRISHNAN
Format Patent
LanguageChinese
English
Published 09.09.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The picsenl invention provides novel compounds represented by the general formula (I): wherein Ar is a quinoline or isoquinoline moiety which is substituted or unsubstituted; B is -O. -S-. or -NH-: R1 is hydrogen or S(O)2R4: R2 is S(O)2R4. C(O)OR5. or C(O)(CH2)n-C(O)OR6: R3 is halogen, cyano, C(O)OR7. or C(O)NR8R9: R4 is aryl: R5 is (C1-C6)alkyl or aryl: R6 is hydrogen. (C1-C4)alkyl. or aryl: R7 is hydrogen or (C1-C4)alkyl: R8 and R9 are independently hydrogen or (C1-C6)alkyl; n is an integer from 1-3: and a pharmaceutically acceptable salt or solvate thereof. their pharmaceutically acceptable salts and their pharmaceutically acceptable solvates thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. The invention also relates to a process for the manufacture of compounds of formula (I) and pharmaceutical compositions containing them.
Bibliography:Application Number: CN2007839695