Pyrimidine derivative as P13K inhibitor and use thereof

Disclosed is a medical agent which is excellent in stability in living bodies and water solubility, while having excellent PI3K inhibitory activity. The medical agent is thus useful for prevention or treatment of cancers. Specifically disclosed is a compound represented by the formula (I) below or a...

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Main Authors YOSHIDA MIYUKI, YAMAMOTO SHUN, KOYAMA KOHEI, NAKAMURA MITSUAKI, HASEGAWA MASAMI, MORIKAMI KENJI, SHIMMA NOBUO, OHWADA JUN, KAWADA HATSUO, EBIIKE HIROSATO, ISHII NOBUYA
Format Patent
LanguageChinese
English
Published 05.08.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed is a medical agent which is excellent in stability in living bodies and water solubility, while having excellent PI3K inhibitory activity. The medical agent is thus useful for prevention or treatment of cancers. Specifically disclosed is a compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. (I) In the formula, X represents a single bond or the like; Y represents a single bond or the like (provided that X and Y are not single bonds at the same time); Z represents a hydrogen atom or the like; m represents an integer of 1 or 2; and R represents a cyclic substituent.
Bibliography:Application Number: CN2007828955