Anti P selectin single-chain antibody and use thereof

• Main Authors: ZHOU YUSEN, ZHANG CHUANFU, LIU XUELIN, SUN YANSONG, XU YUANYONG, SONG HONGBIN, JIN LIANQUN, HUANG LIUYU, JIA LEILI, WANG YONG
• Format: Patent
• Language: Chinese; English
• Published: 17.06.2009
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

The invention discloses a P lectin resistant single chain antibody and application thereof. The invention aims to provide a P lectin resistant genetic engineering single chain antibody and application of the antibody to the preparation of medicines for treating the human body inflammatory reaction. The P lectin resistant single chain antibody can be one of the following amino acid residue sequences: 1) the SEQ ID NO:1 in a sequence list; 2) the protein which is obtained through the substitution, deletion or addition of 1 to 10 amino acid residues to the amino acid residue sequence and has thespecial targeting property for P lectin, a better anti-adhesion/anti-inflammation targeted depression effect, and a good treating effect on the human body inflammatory reaction. The protein has the special targeting property for P lectin, the better anti-adhesion/anti-inflammation targeted depression effect, and the good treating effect on the human body inflammatory reaction. The P lectin resistant single chain antibody