Diglutamate derivates and application thereof in preparation of pemetrexed

The invention relates to a di-glutamate derivative and a preparation method and application in the preparation of pemetrexed thereof. The glutamate derivative is used as a key intermediate for preparing pemetrexed. The method has simple treatment after reaction and high product purity, and facilitat...

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Main Authors WANG JINGYI, LI HONGWEI, ZHANG MINGHUI, GAO YONGHONG, LIU JIANGUO, ZHU YIDONG, LIN DONG, LENG CHUANXIN, WANG LIJUAN, FAN CHUANWEN
Format Patent
LanguageChinese
English
Published 06.05.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a di-glutamate derivative and a preparation method and application in the preparation of pemetrexed thereof. The glutamate derivative is used as a key intermediate for preparing pemetrexed. The method has simple treatment after reaction and high product purity, and facilitates the industrialized production.
Bibliography:Application Number: CN20071113464