Collagen-chitosan spherical honeycombed grain material, producing method and apparatus thereof

• Main Authors: PU YUEPU, LIN PINGHUA, GUO CHAO, CHU CHENGLIN, SHENG XIAOBO, DONG YINSHENG
• Format: Patent
• Language: Chinese; English
• Published: 08.04.2009
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention relates to a collagen-chitosan spherical porous granular material, a method and a device for preparing the same. The preparation method comprises the following steps: step one, the collagen and the chitosan are weighed according to the mass ratio of (1-9) to (9-1); step two, collagen-chitosan acetum solution is prepared; step three, the solution is added into a storage tank from a charging hole, uniformly flows out at a speed of 10 to 60 drops per minute under the condition of the pressure is controlled between 0.08 and 0.5 MPa, and then is dripped into a condensed fluid with a temperature below -(10-20) DEG C in an insulated container for condensation, so as to form the collagen-chitosan spherical porous granular material with good sphericity and homogeneous grain diameter;and step four, the spherical porous grains are separated, undergo freeze drying and then cross-linking treatment for 3 to 24 hours, and are washed, so as to obtain the collagen-chitosan spherical porous granular material. The