Preparation of phenanthroindolizidine derivative

The invention relates to a method for making phenanthrene combined indolizidine derivative. 2,3-diarylate crylic ester or 2,3-diarylate acrylonitril reacts with ferric chloride to firstly produce phenanthrene methyl formate or 9-cyanophenanthrene, which is subsequently hydrolyzed to obtain 9-phenant...

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Bibliographic Details
Main Authors WANG KAILIANG, WANG QINGMIN, LIU YUXIU, LU MAOYUN, HUANG RUNQIU
Format Patent
LanguageChinese
English
Published 20.04.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a method for making phenanthrene combined indolizidine derivative. 2,3-diarylate crylic ester or 2,3-diarylate acrylonitril reacts with ferric chloride to firstly produce phenanthrene methyl formate or 9-cyanophenanthrene, which is subsequently hydrolyzed to obtain 9-phenanthrene formic acid; or 2,3-diarylate crylic acid is coupled with ferric chloride directly to obtain 9-phenanthrene formic acid. Then 9-phenanthrene formic acid is converted to 9-methoxyphenanthrene chloride or 9-phenanthrene formamide, which reacts with pyrrole to produce 2- methoxyphenanthrene pyrrole, which undergoes of carbonyl deoxidization to produce 2- methyl phenanthrene pyrrole, then the pyrrole is deoxidized to obtain 2-methyl phenanthrene tetrahydrogen pyrrole, and finally the ring is closed to obtain phenanthrene combined indolizidine derivative, which react with an inorganic salt or an organic acid to obtain the salt. The invention also provides a method for making 2,3,6,7-tetra methoxy-14- hydroxyl phen
Bibliography:Application Number: CN2007158173